1,000 research outputs found
Searching for hexagonal analogues of the half-metallic half-Heusler XYZ compounds
The XYZ half-Heusler crystal structure can conveniently be described as a
tetrahedral zinc blende YZ structure which is stuffed by a slightly ionic X
species. This description is well suited to understand the electronic structure
of semiconducting 8-electron compounds such as LiAlSi (formulated
Li[AlSi]) or semiconducting 18-electron compounds such as TiCoSb
(formulated Ti[CoSb]). The basis for this is that [AlSi]
(with the same electron count as Si) and [CoSb] (the same electron
count as GaSb), are both structurally and electronically, zinc-blende
semiconductors. The electronic structure of half-metallic ferromagnets in this
structure type can then be described as semiconductors with stuffing magnetic
ions which have a local moment: For example, 22 electron MnNiSb can be written
Mn[NiSb]. The tendency in the 18 electron compound for a
semiconducting gap -- believed to arise from strong covalency -- is carried
over in MnNiSb to a tendency for a gap in one spin direction. Here we similarly
propose the systematic examination of 18-electron hexagonal compounds for
semiconducting gaps; these would be the "stuffed wurtzite" analogues of the
"stuffed zinc blende" half-Heusler compounds. These semiconductors could then
serve as the basis for possibly new families of half-metallic compounds,
attained through appropriate replacement of non-magnetic ions by magnetic ones.
These semiconductors and semimetals with tunable charge carrier concentrations
could also be interesting in the context of magnetoresistive and thermoelectric
materials.Comment: 11 pages, 6 figures, of which 4 are colou
Delta degrees of freedom in antisymmetrized molecular dynamics and (p,p') reactions in the delta region
Delta degrees of freedom are introduced into antisymmetrized molecular
dynamics (AMD). This is done by increasing the number of basic states in the
AMD wave function, introducing a Skyrme-type delta-nucleon potential, and
including reactions in the collision description.
As a test of the delta dynamics, the extended AMD is applied to (p,p)
recations at MeV for a C target. It is found that the
ratio and the absolute values for delta peak and quasielastic peak (QEP) in the
C(p,p) reaction are reproduced for angles \Theta_{\rm lab} \agt
40^\circ, pointing to a correct treatment of the delta dynamics in the
extended AMD. For forward angles the QEP is overestimated. The results of the
AMD calculations are compared to one-step Monte Carlo (OSMC) calculations and a
detailed analysis of multi-step and delta potential effects is given. As
important side results we present a way to apply a Gallilei invariant theory
for (N,N) reactions up to MeV which ensures
approximate Lorentz invariance and we discuss how to fix the width parameter
of the single particle momentum distribution for outgoing nucleons in the
AMD calculation.Comment: 28 pages, revtex, 12 figures included, figures are also available
upon request as postscript files from the authors (e-mail:
[email protected]), submitted to Phys. Rev.
Carbon Isotopes Near Drip Lines in the Relativistic Mean-Field Theory
We have investigated the ground-state properties of carbon isotopes in the
framework of the relativistic mean-field (RMF) theory. RMF calculations have
been performed with the non-linear scalar self-coupling of the meson
using an axially symmetric deformed configuration. We have also introduced the
vector self-coupling of the meson for the deformed mean-field
calculations. The results show that the RMF predictions on radii and
deformations are in good agreement with the available experimental data. It is
shown that several carbon isotopes possess a highly deformed shape akin to a
superdeformation. The single-particle structure of nuclei away from the
stability line has been discussed with a view to understand the properties near
the neutron drip line. Predictions of properties of carbon isotopes away from
the stability line are made.Comment: Revtex, 29 pages, 11 postscript figures include
Grain Dynamics in a Two-dimensional Granular Flow
We have used particle tracking methods to study the dynamics of individual
balls comprising a granular flow in a small-angle two-dimensional funnel. We
statistically analyze many ball trajectories to examine the mechanisms of shock
propagation. In particular, we study the creation of, and interactions between,
shock waves. We also investigate the role of granular temperature and draw
parallels to traffic flow dynamics.Comment: 17 pages, 24 figures. To appear in Phys.Rev.E. High res./color
figures etc. on http://www.nbi.dk/CATS/Granular/GrainDyn.htm
Velocity and density profiles of granular flow in channels using lattice gas automaton
We have performed two-dimensional lattice-gas-automaton simulations of
granular flow between two parallel planes. We find that the velocity profiles
have non-parabolic distributions while simultaneously the density profiles are
non-uniform. Under non-slip boundary conditions, deviation of velocity profiles
from the parabolic form of newtonian fluids is found to be characterized solely
by ratio of maximal velocity at the center to the average velocity, though the
ratio depends on the model parameters in a complex manner. We also find that
the maximal velocity () at the center is a linear function of the
driving force (g) as with non-zero in
contrast with newtonian fluids. Regarding density profiles, we observe that
densities near the boundaries are higher than those in the center. The width of
higher densities (above the average density) relative to the channel width is a
decreasing function of a variable which scales with the driving force (g),
energy dissipation parameter () and the width of the system (L) as
with exponents and . A phenomenological theory based on a scaling argument is presented to
interpret these findings.Comment: Latex, 15 figures, to appear in PR
Delta excitation in K^+-nucleus collisions
We present calculations for \Delta excitation in the (K^+,K^+) reaction in
nuclei. The background from quasielastic K^+ scattering in the \Delta region is
also evaluated and shown to be quite small in some kinematical regions, so as
to allow for a clean identification of the \Delta excitation strength. Nuclear
effects tied to the \Delta renormalization in the nucleus are considered and
the reaction is shown to provide new elements to enrich our knowledge of the
\Delta properties in a nuclear medium.Comment: 11 pages, 6 figures, LaTe
Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease
Background:
Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with macrophage levels in inflammatory bowel disease (IBD). In vitro experiments tested the ability of macrophages to induce senescence in primary cells. Inflammation modulating microRNAs were identified in senescence colon tissue for further investigation.
Methodology/Principal Findings:
Quantitative immunohistochemistry identified protein expression by colon cell type. Increased cellular senescence (HP1γ; P = 0.01) or DDR (γH2A.X; P = 0.031, phospho-Chk2, P = 0.014) was associated with high macrophage infiltration in UC. Co-culture with macrophages (ANA-1) induced senescence in >80% of primary cells (fibroblasts MRC5, WI38), illustrating that macrophages induce senescence. Interestingly, macrophage-induced senescence was partly dependent on nitric oxide synthase, and clinically relevant NO• levels alone induced senescence. NO• induced DDR in vitro, as detected by immunofluorescence. In contrast to UC, we noted in Crohn’s disease (CD) that senescence (HP1γ; P<0.001) and DDR (γH2A.X; P<0.05, phospho-Chk2; P<0.001) were higher, and macrophages were not associated with senescence. We hypothesize that nitric oxide may modulate senescence in CD; epithelial cells of CD had higher levels of NOS2 expression than in UC (P = 0.001). Microarrays and quantitative-PCR identified miR-21 expression associated with macrophage infiltration and NOS2 expression.
Conclusions:
Senescence was observed in IBD with senescence-associated β-galactosidase and HP1γ. Macrophages were associated with senescence and DDR in UC, and in vitro experiments with primary human cells showed that macrophages induce senescence, partly through NO•, and that NO• can induce DDR associated with senescence. Future experiments will investigate the role of NO• and miR-21 in senescence. This is the first study to implicate macrophages and nitrosative stress in a direct effect on senescence and DDR, which is relevant to many diseases of inflammation, cancer, and aging.Cancer Research Institute (New York, N.Y.) (Intramural Research Program)National Cancer Institute (U.S.) (Cancer Research Training Award Fellowship)Danish Cancer SocietyDanish National Research FoundationEuropean Commission (projects: Infla-Care, Biomedreg and DDResponse
Coherent pion production in neutrino nucleus collision in the 1 GeV region
We calculate cross sections for coherent pion production in nuclei induced by
neutrinos and antineutrinos of the electron and muon type. The analogies and
differences between this process and the related ones of coherent pion
production induced by photons, or the (p,n) and reactions are
discussed. The process is one of the several ones occurring for intermediate
energy neutrinos, to be considered when detecting atmospheric neutrinos. For
this purpose the results shown here can be easily extrapolated to other
energies and other nuclei.Comment: 13 pages, LaTex, 8 post-script figures available at
[email protected]
A boundary exchange influence on deglacial neodymium isotope records from the deep western Indian Ocean
The use of neodymium (Nd) isotopes to reconstruct past water mass mixing relies upon the quasi-conservative behaviour of this tracer, whereas recent studies in the modern oceans have suggested that boundary exchange, involving the addition of Nd from ocean margin sediments, may be an important process in the Nd cycle. Here we suggest that the relative importance of water mass advection versus boundary exchange can be assessed where the deep western boundary current in the Indian Ocean flows past the Madagascan continental margin; a potential source of highly unradiogenic Nd. Foraminiferal coatings and bulk sediment reductive leachates are used to reconstruct bottom water Nd isotopic composition (εNd) in 8 Holocene age coretops, with excellent agreement between the two methods. These data record spatial variability of ∼4 εNd units along the flow path of Circumpolar Deep Water; εNd≈−8.8 in the deep southern inflow upstream of Madagascar, which evolves towards εNd≈−11.5 offshore northern Madagascar, whereas εNd≈−7.3 where deep water re-circulates in the eastern Mascarene Basin. This variability is attributed to boundary exchange and, together with measurements of detrital sediment εNd, an isotope mass balance suggests a deep water residence time for Nd of ≤400 yr along the Madagascan margin. Considering deglacial changes, a core in the deep inflow upstream of Madagascar records εNd changes that agree with previous reconstructions of the Circumpolar Deep Water composition in the Southern Ocean, consistent with a control by water mass advection and perhaps indicating a longer residence time for Nd in the open ocean away from local sediment inputs. In contrast, sites along the Madagascan margin record offset εNd values and reduced glacial–interglacial variability, underlining the importance of detecting boundary exchange before inferring water mass source changes from Nd isotope records. The extent of Madagascan boundary exchange appears to be unchanged between the Holocene and Late Glacial periods, while a consistent shift towards more radiogenic εNd values at all sites in the Late Glacial compared to the Holocene may represent a muted signal of a change in water mass source or composition
The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches
The feasibility of a next generation neutrino observatory in Europe is being
considered within the LAGUNA design study. To accommodate giant neutrino
detectors and shield them from cosmic rays, a new very large underground
infrastructure is required. Seven potential candidate sites in different parts
of Europe and at several distances from CERN are being studied: Boulby (UK),
Canfranc (Spain), Fr\'ejus (France/Italy), Pyh\"asalmi (Finland),
Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The
design study aims at the comprehensive and coordinated technical assessment of
each site, at a coherent cost estimation, and at a prioritization of the sites
within the summer 2010.Comment: 5 pages, contribution to the Workshop "European Strategy for Future
Neutrino Physics", CERN, Oct. 200
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